Recent structures determined using the resources of the Macromolecular Crystallography Facility.

N. Yan, J.R. Huh, V. Schirf, B. Demeler, B.A. Hay, Y. Shi (2006) Structure and activation mechanism of the Drosophila initiator caspase Dronc. J Biol Chem 281, 8667-74. PDB entry 2FP3.
M. Hu, L. Gu, M. Li, P.D. Jeffrey, W. Gu, Y. Shi (2006) Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol 4, e27. PDB entry 2F1W.
F.Y. Li, P.D. Jeffrey, J.W. Yu, Y. Shi (2006) Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signaling. J Biol Chem 281, 2960-8. PDB entry 2F1S.
M. Hu, P. Li, L. Song, P.D. Jeffrey, T.A. Chenova, K.D. Wilkinson, R.E. Cohen, Y. Shi (2005) Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J 24, 3747-56. PDB entry 2AYN.
N. Yan, J. Chai, E.S. Lee, L. Gu, Q. Liu, J. He, J.W. Wu, D. Kokel, H. Li, Q. Hao, D. Xue, Y. Shi (2005) Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature 437, 831-7. PDB entry 2A5Y.
Y. Chao, E.N. Shiozaki, S.M. Srinivasula, D.J. Rigotti, R. Fairman R, Y. Shi (2005) Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. PLoS Biol 3, e183. PDB entry 2AR9.
L. Feng, S. Zhou, L. Gu, D.A. Gell, J.P. Mackay, M.J. Weiss, A.J. Gow, Y. Shi (2005) Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem. Nature 435, 697-701. PDB entry 1Z8U.
M.B. Neiditch, M.J. Federle, S.T. Miller, B.L. Bassler, F.M. Hughson (2005) Regulation of LuxPQ receptor activity by the quorum-sensing signal autoinducer-2. Mol Cell 18, 507-18. PDB entry 1ZHH.
S.J. Riedl, W. Li, Y. Chao, R. Schwarzenbacher, Y. Shi (2005) Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature 434, 926-33. PDB entry 1Z6T.

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