Pinter, Aubert, Zakian. (2008, in press) The S. pombe Pfh1p DNA helicase is essential for the maintenance of nuclear and mitochondrial DNA. Mol Cell Biol.

Sabourin M, Zakian VA. (2008) ATM-like kinases and regulation of telomerase: lessons from yeast and mammals. Trends Cell Biol. 18: 337-346. PubMed

Webb CJ, Zakian VA. (2008) Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA. Nat Struct Mol Biol. 15: 34-42. PubMed

Mondoux MA, Scaife JG, Zakian VA. (2007) Differential nuclear localization does not determine the silencing status of Saccharomyces cerevisiae telomeres. Genetics 177: 2019-2029. PubMed

Mondoux MA, Zakian VA. (2007) Subtelomeric elements influence but do not determine silencing levels at Saccharomyces cerevisiae telomeres. Genetics 177: 2541-2546. PubMed

Boulé JB, Zakian VA. (2007) The yeast Pif1p DNA helicase preferentially unwinds RNA DNA substrates. Nucleic Acids Res 35: 5809-5818. PubMed

Sabourin M, Tuzon, CTT, Zakian VA (2007). Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae. Mol Cell. 27: 550-561. PubMed

Vega LR, Phillips J, Thornton BR, Benanti JA, Onigbanjo MT, Toczyski DP, Zakian VA (2007). Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase. PLoS Genet 3: 1065-1075. PubMed

Bhasakara V, Dupre A, Lengsfeld B, Hopkins B, Lee J-H, Zhang X, Gautier J, Zakian VA, Paull TT (2007). Rad50 Adenylate kinase activity regulates DNA tethering activities of Mre11/Rad50 complexes. Mol Cell 25: 647-661. PubMed

Sabourin M, Tuzon CT, Fisher TS, and Zakian VA (2007). A flexible protein linker improves the function of epitope tagged protein in S. cerevisiae. Yeast 24: 39-45. PubMed.

Snow BE, Mateyak M, Paderova J, Wakeham A, Iorio C, Zakian V, Squire J, Harrington L. (2007). Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo. Mol Cell Biol 27: 1017-1026. PubMed

Azvolinsky A, Dunaway S, Torres JZ, Bessler JB, and Zakian VA (2006). The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes. Genes Dev 20: 3104-3116. PubMed

Mateyak, MK and Zakian VA (2006) Human PIF helicase is cell cycle regulated and associates with telomerase. Cell Cycle 5: 23. PubMed

Goudsouzian, LK, Tuzon, CT and Zakian, VA (2006) S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association. Mol Cell 24: 603-610. PubMed

Boulé JB and Zakian VA (2006). Roles of Pif1-like helicases in the maintenance of genomic stability. Nucl Acids Res. 34: 4147-4153. PubMed

Sealey DCF, Zakian VA, and Harrington L (2006). Telomere DNA Replication, Telomerase and Human Disease. In DNA replication and human disease (ed. M.L. DePamphilis), pp. 561-592. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

Boulé, JB*, Vega LR*, and Zakian VA (2005). The Yeast Pif1p helicase removes telomerase from DNA. (*these authors contributed equally). Nature 438: 57-61

Fisher TS and Zakian VA (2005) Ku at the telomere. DNA Rep 4: 1215-1226.

Mondoux MA and Zakian VA (2005) Telomere position effect: silencing near the end. In Telomeres, 2nd edition (edited by de Lange, T, Lundblad, V, Blackburn, EH) CSH press. Pp. 261-316.

Fisher TS, Taggart AKP, and Zakian VA (2004). The interaction of Ku and TLC1 telomerase RNA promotes the cell cycle-dependent telomere association of telomerase in Saccharomyces cerevisiae. Nat Struct Mol Biol. 11:1198-1205. Abstract

Bessler JB and Zakian VA (2004). The amino terminus of the Saccharomyces cerevisiae DNA helicase Rrm3p modulates protein function altering replication and checkpoint activity. Genetics 168: 1205-1218. Abstract

Torres JZ, Schnakenberg SL, and Zakian VA (2004). The Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra S phase checkpoint and fork restart activities. Mol Cell Biol. 24: 3198-3212. Abstract

Torres, JZ*, Bessler, JB*, and Zakian VA (2004). Local chromatin structure at the ribosomal DNA causes replication fork pausing and genome instability in the absence of the S. cerevisiae DNA helicase Rrm3p. (*co-first authors) Genes Dev. 18: 498-503. Abstract

Ivessa AS, Lenzmeier,BA, Bessler JB, Goudsouzian LK, Schnakenberg SL, and Zakian VA (2003). The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes. Mol Cell 12:1525-1536. Abstract

Vega LR, Mateyak MK and Zakian VA (2003). Getting to the end: telomerase access in yeast and humans. Nat Rev Mol Cell Biol. 4: 948-959. Abstract

Callahan JL, Andrews KJ, Zakian VA and Freudenreich CH (2003). Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility. Mol Cell Biol. 23: 7849-7860. Abstract

Taggart AKP and Zakian VA (2003). Telomerase: what are the Est proteins doing? Curr Opin Cell Biol. 15: 275-280. Abstract

Alexander MK and Zakian VA (2003). Rap1p telomere association is not required for mitotic stability of a C3TA2 telomere in yeast. EMBO J. 22: 1688-1696. Abstract

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Ivessa, IS and Zakian VA (2002). To fire or not to fire: origin activation in Saccharomyces cerevisiae ribosomal DNA. Genes Dev. 16: 2459-2464.

Taggart AKP, Teng S-C and Zakian VA (2002). Est1p as a cell cycle regulated activator of telomere-bound telomerase. Science 297:1023-1026. Abstract | Methods

Tham W-H and Zakian VA (2002). Transcriptional silencing at Saccharomyces telomeres: implications for other organisms. Oncogene 21: 512-521. Abstract

Zhou J-Q, Qi H, Schulz VP, Mateyak MK, Monson EK, and Zakian VA (2002). S. pombe php1⁺ encodes an essential 5' to 3' DNA helicase that is a member of the PIF1 sub-family of DNA helicases. Mol Biol Cell 13: 2180-2191. Abstract

Ivessa AS, Zhou J-Q, Schulz VP, Monson EK, and Zakian VA (2002). The Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and sub-telomeric DNA. Genes Dev 16: 1383-1396. Abstract

Mangahas JL, Alexander MK, Sandell LL, and Zakian VA (2001). Repair of chromosome ends after telomere loss in Saccharomyces. Mol Biol Cell 12: 4078-4089. Abstract

Tsukamoto Y, Taggart AKP, and Zakian VA (2001). The role of the Mre11-Rad50-Xrs2 complex in telomerase mediated lengthening of Saccharomyces telomeres. Curr Biol 11: 1328-1335. Abstract

Tham W-H, Wyithe JSB, Ko Ferrigno P, Silver PA, and Zakian VA (2001). Localization of yeast telomeres to the nuclear periphery is separable from transcriptional repression and telomere stability functions. Mol Cell 8: 189-199. Abstract

Bessler JB, Torres JZ, and Zakian VA (2001) The Pif1p subfamily of helicases: region specific DNA helicases? Trends Cell Biol 11: 60-65. Abstract

Teng S-C, Chang J, McCowan B, and Zakian VA (2000) Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process. Mol Cell 6: 947-952. Abstract

de Bruin D, Kantrow SM, Liberatore RA, and Zakian VA (2000) Chromatin remodeling and transcriptional reactivation of a telomere-linked gene independent of DNA replication. Mol Cell Biol 20: 7991-8000. Abstract

Tham W-H and Zakian VA (2000). Telomeric tethers. Nature 403: 34-35.

Balakumaran BS, Freudenreich CH, and Zakian VA (2000). CGG/CCG repeats exhibit orientation dependent instability and orientation independent fragility in Saccharomyces cerevisiae. Hum Mol Genet 9: 93-100. Abstract

Zhou J-Q, Monson EK, Teng S-C, Schulz VP, and Zakian VA (2000). Pif1p helicase, a catalytic inhibitor of telomerase in yeast. Science 289: 771-774. Abstract

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Qi H and Zakian VA (2000). The Saccharomyces telomere binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase a and the telomerase associated Est1 protein. Genes Dev 14: 1777-1788. Abstract

Ivessa AS, Zhou J-Q, and Zakian VA (2000). The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 100: 479-489. Abstract

Teng SC and Zakian VA (1999). Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae. Mol Cell Biol 19: 8083-8093. Abstract

Stavenhagen JB and Zakian VA (1998). Yeast telomeres exert a position effect on recombination between internal tracts of yeast telomeric DNA. Genes Dev 12: 3044-3058. Abstract

Bourns BB, Alexander MK, Smith AM, and Zakian VA (1998) Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo. Mol Cell Biol 18: 5600-5608. Abstract

Freudenreich CH, Kantrow SM, and Zakian VA (1998) Expansion and length-dependent fragility of CTG repeats in yeast. Science 279: 853-856. Abstract

Monson EK, DeBriun D, and Zakian VA (1997). The yeast Cac1 protein is required for the stable inheritance of transcriptionally repressed chromatin at telomeres. PNAS 94: 13081-13086. Abstract

Zakian VA (1997) Life and cancer without telomerase. Cell 91: 1-3. Abstract

Freudenreich CH, Stavenhagen JB, and Zakian VA (1997) Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome. Mol Cell Biol 17: 2090-2098. Abstract

Lin JJ and Zakian VA (1996) The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA binding protein in vitro that affects telomere behavior in vivo. PNAS 93: 13760-13765. Abstract

Zakian VA (1996) Structure, function and replication of Saccharomyces cerevisiae telomeres. Annu Rev Genet 30: 141-172. Abstract

Schulz VP, Zakian VA, Ogburn CE, McKay J, Jarzebowicz AA, Edland SD, Martin GM (1996) Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Hum Genet 97: 750-754. Abstract

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Runge KW and Zakian VA (1996) TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 16: 3094-3105. Abstract

Wellinger RJ, Etier K, Labreque P, and Zakian VA (1996) Evidence for a new step in telomere maintenance. Cell 85: 423-433. Abstract

Zakian VA (1995) ATM-related genes: what do they tell us about functions of the human gene? Cell 82: 685-687.

Lin JJ and Zakian VA (1995) An in vitro assay for Saccharomyces telomerase requires EST1. Cell 81: 1127-1135. Abstract

Zakian VA (1995) Telomeres: beginning to understand the end. Science 270: 1601-1607. Abstract

Wright JH and Zakian VA (1995) Protein-DNA interactions in soluble telosomes from Saccharomyces cerevisiae. Nucl Acids Res 23:1454-1460. Abstract

Wiley E and Zakian VA (1995) Extra telomeres, but not internal tracts of telomeric DNA, reduce transcriptional repression at Saccharomyces telomeres. Genetics 139: 67-79. Abstract

Lin J-J and Zakian VA (1994) Isolation and characterization of two Saccharomyces genes that encode proteins that bind to TG_1-3 single-strand telomeric DNA in vitro. Nucl Acids Res 22: 4906-4913. Abstract

Sandell LL, Gottschling DE, and Zakian VA (1994) Transcription through a yeast telomere reduces telomere position effect without affecting chromosome stability. PNAS 91: 12061-12065. Abstract

Stavenhagen J and Zakian VA (1994) Internal tracts of telomeric DNA act as silencers in Saccharomyces cerevisiae. Genes Dev 8: 1411-1422. Abstract

Schulz VP and Zakian VA (1994) The Saccharomyces PlFl DNA helicase inhibits telomere elongation and de novo telomere formation Cell 76: 145-155. Abstract

Sandell LL and Zakian VA (1993) Loss of a yeast telomere: arrest, recovery and chromosome loss. Cell 75: 729-739. Abstract

Wellinger RJ, Wolf AJ, and Zakian VA (1993) Origin activation and formation of single-strand TG1-3 tails occur sequentially in late S phase on a linear plasmid. Mol Cell Biol 13: 4057-4065. Abstract

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Wellinger RJ, Wolf A, and Zakian VA (1993) Single strand TG1-3 tails acquired by Saccharomyces telomeres late in S phase mediate telomere-telomere interactions. Cell 72: 51-60. Abstract

Wright JH, Gottschling DE, and Zakian VA (1992) Saccharomyces telomeres assume a non-nucleosomal chromatin structure. Genes Dev 6: 197-210. Abstract

Conrad MN, Wright J, Wolf A, and Zakian VA (1990) RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability. Cell 63: 739-750. Abstract

Gottschling DE, Aparicio DM, Billington BL, and Zakian VA (1990) Position effect at Saccharomyces cerevisiae telomeres: reversible repression of polII transcription. Cell 63: 751-762. Abstract

Wang S-S and Zakian VA (1990) Sequence analysis of Saccharomyces telomeres cloned using T4 DNA polymerase reveals two domains. Mol Cell Biol 10: 4415-4419.

Wang S-S and Zakian VA (1990) Telomere-telomere recombination provides an express pathway for telomere acquisition. Nature 345: 456-458.

Zakian VA (1989) Structure and function of telomeres. Ann Rev Genet 23: 579-604.

Pluta AF and Zakian VA (1989) Recombination occurs during telomere formation in Saccharomyces cerevisiae. Nature 337: 429-433.

Gottschling DE and Zakian VA (1986) Telomere Proteins: Specific recognition and protection of natural termini of Oxytricha macronuclear DNA. Cell 47: 195-205.

Pluta AF, Dani GM, Spear BB, and Zakian VA (1984) Elaboration of telomeres in yeast: Recognition and modification of termini from Oxytricha macronuclear DNA. PNAS 81: 1475-1479.

Dani GM and Zakian VA (1983) Mitotic and meiotic stability of linear plasmids in yeast. PNAS 80: 3406-3410.

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