Biker worm Boarder worm Striker worm Swimmer worm

the murphy lab
@ Princteon University
publications

2017

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Shi, C., Runnels, A.M., and Murphy, C.T.
Mating and Male pheromone kill Caenorhabditis males through distinct mechanisms.

eLIFE (2017) Mar 14;6. pii: e23493.

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Son, H.G., Seo, M., Ham, S., Hwang, W., Lee, D., An, S.W., Artan, M., Seo, K., Kaletsky, R., Arey, R.N., Ryu, Y., Ha, C.M., Kim, Y.K., Murphy, C.T., Roh, T.Y., Nam, H.G., and Lee, S.V.
RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

Nature Communications (2017)
Mar 9;8:14749

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Arey, R.N., and Murphy, C.T.
Conserved regulators of cognitive aging: From worms to humans.

Behavioural Brain Research (2017) Mar 30;322(Pt B):299-310.

2016

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Shi, C., and Murphy, C.T. Feeding the germline.
Genes & Development
(2016) Feb 1;30(3):249-50.

Crocker, A., Guan, X.J., Murphy, C.T., and Murthy, M. Cell Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression. Cell Reports (2016) accepted.

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Li, L., Lei, H., Arey, R.N., Li, P., Liu, J., Murphy, C.T., Xu, S.X.Z., and Shen, K. The neuronal kinesin UNC-104/KIF1A is a key regulator of synaptic aging and insulin signaling-related memory. Current Biology (2016) in press.  co‑corresponding authors.

2015

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Shi, C., Runnels, A.M., and Murphy, C.T. Mating-induced Male Death and Pheromone Toxin-related Androstasis. bioRxiv (2015) Dec 15; preprint.

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DiLoreto, R., and Murphy, C.T. The Cell Biology of Aging. Molecular Biology of the Cell (2015) Dec 15; 26(25):4524-31.

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Kaletsky, R., Lakhina, V., Arey, R., Williams, A., Landis, J., Ashraf, J., and Murphy, C.T. The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators. Nature (2015) Dec 14; 529(7584):92-96. These authors contributed equally to this work.

Research Highlight
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Wang, J., Kaletsky, R., Silva, M., Williams, A., Haas, L.A., Androwski, R.J., Landis, J.N., Patrick, C., Rashid, A., Santiago-Martinez, D., Gravato-Nobre, M., Hodgkin, J., Hall, D.H., Murphy, C.T., and Barr, M.M. Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis. Current Biology (2015) Dec 21; 25(24):R1168-1170.

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Lakhina, V., and Murphy, C.T. Genome Sequencing Fishes out Longevity Genes. Cell (2015) Dec 3; 163(6):1312-1313.

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Hahm, J.H., Kim, S., DiLoreto, R., Shi, C., Lee, S.J.V., Murphy C.T., and Nam, H.G. C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation. Nature Communications (2015) Nov 20; 6:8919. These authors contributed equally to this work.  co‑corresponding authors.

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Ewald, C.Y., Landis, J.N., Abate, J.P., Murphy, C.T., and Blackwell, T.K. Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature (2014) March 5; 519(7541): 97-101. These authors contributed equally to this work.  co‑corresponding authors.

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Lakhina, V., and Murphy, C.T. For Longevity, Perception is Everything. Cell (2015) Feb 26; 160(5):807-809.

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Lakhina, V., Arey, R.N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C.T. Genome-wide Functional Analysis of CREB/Long-Term Memory-Dependent Transcription Reveals Distinct Basal and Memory Gene Expression Programs. Neuron (2015) Jan 21; 85(2): 330-345. These authors contributed equally to this work.

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Li, S., Stone, H.A., and Murphy, C.T. A microfluidic device and automatic counting system for the study of C. elegans reproductive aging. Lab on a Chip (2015) Jan 21; 15(2): 524-31.

2014

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Stein, G.M., and Murphy, C.T. C. elegans positive olfactory associative memory is a molecularly conserved behavioral paradigm. Neurobiology of Learning and Memory (2014) Aug 7; 115: 86-94.

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Fernandes de Abreu, D.A., Caballero, A., Fardel, P., Stroustrup, N., Chen, Z., Lee, K., Keyes, W.D., Nash, Z.M., López-Moyado I.F., Vaggi, F., Cornils, A., Regenass, M., Neagu, A., Ostojic, I., Liu, C., Cho, Y., Sifoglu, D., Shen, Y., Fontana, W., Lu, H., Csikasz-Nagy, A., Murphy, C.T., Antebi, A., Blanc, E., Apfeld, J., Zhang, Y., Alcedo, J., Ch'ng, Q. An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology. PLoS Genetics (2014) March 27; 10(3): e1004225. These authors contributed equally to this work.  co‑corresponding authors.

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Shi, C. and Murphy, C.T. Mating Induces Shrinking and Death in Caenorhabditis Mothers. Science (2014) Jan 31; 343(6170): 536-540.

Research Highlights
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Tepper, R.G., Murphy, C.T., and Bussemaker, H.J. DAF-16 and PQM-1: Partners in longevity. Aging (Albany, NY) (2014) Jan 6; 6(1): 5-6.

2013

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Murphy, C.T., and Hu, P.J. Insulin/insulin-like growth factor signaling in C elegans. WormBook (2013) Dec 26; The C elegans Research Community, WormBook 1.164.1: 1-43.  corresponding author.

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Caudy, A.A., Guan, Y., Jia, Y., Hansen, C., DeSevo, C., Hayes, A.P., Agee, J., Alvarez-Dominguez, J.R., Arellano, H., Barrett, D., Bauerle, C., Bisaria, N., Bradley, P.H., Breunig, J.S., Bush, E., Cappel, D., Capra, E., Chen, W., Clore, J., Combs, P.A., Doucette, C., Demuren, O., Fellowes, P., Freeman, S., Frenkel E., Gadala-Maria, D., Gawande, R., Glass, D., Grossberg, S., Gupta, A., Hammonds-Odie, L., Hoisos, A., Hsi, J., Hsu, Y.H., Inukai, S., Karczewski, K.J., Ke, X., Kojima, M., Leachman, S., Leiber, D., Liebowitz, A., Liu, J., Liu, Y., Martin, T., Mena, J., Mendoza, R., Myhrvold, C., Millian, C., Pfau, S., Raj, S., Rich, M., Rokicki, J., Rounds, W., Salazar, M., Salesi, M., Sharma, R., Silverman, S., Singer, C., Sinha, S., Staller, M., Stern, P., Tang, H., Weeks, S., Weidmann, M., Wolf, A., Young, C., Yuan, J., Cruchfield, C., McClean, M., Murphy, C.T., Linaás, M., Botstein, D., Troyanskaya, O.G., and Dunham, M.J. A new system for comparative functional genomics of Saccharomyces yeasts. Genetics (2013) July 12; 195(1): 275-287.

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Tepper, R.G., Ashraf, J., Kaletsky, R., Kleeman, G., Murphy, C.T., and Bussemaker, H.J. PQM-1 Complements DAF-16 as a Key Transcriptional Regulator of DAF-2-Mediated Development and Longevity. Cell (2013) Aug 1; 154(3): 676-690. These authors contributed equally to this work.  co‑corresponding authors.

2012

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Blackstone, C. and Murphy, C.T. Cell biology of disease and aging: a two-way street. Molecular Biology of the Cell (2013) Mar 15; 23(6): 975.

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Stein, G.M. and Murphy, C.T. The intersection of aging, longevity pathways, and learning and memory in C. elegans. Frontiers in Genetics (2012) Nov 26; 3:259.

2011

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Liu, G., Rogers, J., Murphy, C.T., and Rongo, C. EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan. The EMBO Journal (2011) Aug 3; 30(15): 2990-3003.

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Rizki, G., Iwata, T.N., Li, J., Riedel, C.G., Picard, C.L., Jan, M., Murphy, C.T., and Lee, S.S. The evolutionary conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genetics (2011) Sept 1; 7(9): e1002235.

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Luo, S. and Murphy, C.T. Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms. Genesis (2011) Jan 24; 49(2): 53-65.

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Kauffman, A., Parsons, L., Stein, G., Wills, A., Kaletsky, R., and Murphy, C.T. C. elegans positive butanone learning, short-term, and long-term associative memory assays. Journal of Visualized Experiments (2011) March 11; (49): e2490.

2010

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Murphy, C.T. Aging: miRacles of longevity? Current Biology (2010) Dec 21; 20(24): R1076-R1078.

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Luo, S., Kleeman, G.A., Ashraf, J.M., Shaw, W.M., and Murphy, C.T. TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance. Cell (2010) Oct 15; 143(2): 299-312.

Research Highlights
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Kaletsky, R. and Murphy, C.T. The role of insulin/IGF-like signaling in C. elegans longevity and aging. Disease Models & Mechanisms (2010) July 1; 3(7-8): 415-419.

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Kauffman, A.L., Ashraf, J.M., Corces-Zimmerman, M.R., Landis, J.N., and Murphy, C.T. Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. PLoS Biology (2010) May 18; 8(5): e1000372.

Research Highlight
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Landis, J.N. and Murphy, C.T. Integration of Diverse Inputs in the Regulation of Caenorhabditis elegans DAF-16/FOXO. Developmental Dynamics (2010) Jan 5; 239(5): 1405-1412.

2009

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Luo, S., Shaw, W.M., Ashraf, J., and Murphy C.T. TGF-β Sma/Mab Signaling Mutations Uncouple Reproductive Aging from Somatic Aging. PLoS Genetics (2009) Dec 24; 5(12): e1000789.

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Lee, S.J., Murphy, C.T., and Kenyon, C. Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metabolism (2009) Nov 4; 10(5): 379-391.

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Oliveira, R.P., Abate, J.P., Dilks, K., Landis, J.N., Ashraf, J., Murphy, C.T., and Blackwell, K.T. Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell (2009) July 3; 8(5): 524-541. These authors contributed equally to this work.  co‑corresponding authors.

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Chikina, M.D., Huttenhower, C., Murphy, C.T., and Troyanskaya, O.G. Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans. PLoS Computational Biology (2009) June 19; 5(6): e1000417. co‑corresponding authors.

Kleeman, G.A. and Murphy, C.T. The endocrine regulation of aging in Caenorhabditis elegans. Molecular and Cellular Endocrinology (2009) Feb 5; 299(1): 51-57.

2007

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Murphy, C.T., Lee, S.J., and Kenyon, C. Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proceedings of the National Academy of Sciences (2007) Nov 27; 104(48): 19046-19050.

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Shaw, W.M., Luo, S., Landis, J., Ashraf, J., and Murphy, C.T. The C. elegans TGF-β Dauer pathway regulates longevity via insulin signaling. Current Biology (2007) Oct 9; 17(19): 1635-1645.

2006

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Murphy, C.T. The search for DAF-16/FOXO transcriptional targets: Approaches and discoveries. Experimental Gerontology (2006) Oct 9; 41(10): 910-21.

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Murphy, C.T. Using Whole-Genome Transcriptional Analyses to Discover Molecular Mechanisms of Aging. Drug Discovery Today: Disease Mechanisms (2006) May 9; 3(1): 41-46.

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Kenyon, C. and Murphy, C.T. Enrichment of regulatory motifs upstream of predicted DAF-16 targets. Nature Genetics (2006) Apr; 38(4): 397-8; author reply 398.

2005

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Murphy, C.T. A review of genes that act downstream of the DAF-16 FOXO transcription factor to influence the life span of C. elegans. Longevity and Frailty (2005) 27-37.

2004

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McCarroll, S.A., Murphy, C.T., Zou, S., Pletcher, S.D., Chin, C.S., Jan, Y.N., Kenyon, C., Bargmann, C.I., and Li, H. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nature Genetics (2004) Jan 18; 36(2): 197-204.

2003

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Murphy, C.T., McCarroll, S.A., Bargmann, C.I., Fraser, A., Kamath, R.S., Ahringer, J., Li, H., and Kenyon, C. Genes that Act Downstream of DAF-16 to Influence the Lifespan of C. elegans. Nature (2003) June 29; 424(6946): 277-83.

Research Highlight
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Hsu, A.L., Murphy, C.T., and Kenyon, C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science (2003) May 16; 300(5622): 1142-1145.

2001

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Murphy, C.T., Rock, R.S., and Spudich, J.A. A Myosin II Mutation Uncouples ATPase activity from Mobility and Shortens Step Size. Nature Cell Biology (2001) Feb 16; 3(3): 311-315.

2000

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Murphy, C.T. and Spudich, J.A. Variable Surface Loops and Myosin Activity: Accessories to a Motor. Journal of Muscle Research and Cell Motility (2000) Feb; 21(2): 139-151.

1999

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Murphy, C.T. and Spudich, J.A. The Sequence of the Myosin 50−20K Loop Affects Myosin's Affinity for Actin throughout the Actin−Myosin ATPase Cycle and Its Maximum ATPase Activity. Biochemistry (1999) Mar 5; 38(12): 3785-3792.

1998

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Murphy, C.T. and Spudich, J.A. Dictyostelium myosin 25-50K loop substitutions specifically affect ADP release rates. Biochemistry (1998) Apr 22; 37(19): 6738-6744.