Biker worm Boarder worm Striker worm Swimmer worm

the murphy lab
@ Princteon University
Rachel Arey

Rachel Arey

I am a relative newcomer to the East Coast. I grew up in Texas, and completed my undergraduate and graduate studies there before moving to Princeton for my postdoc. I had never worked with C. elegans before coming to the Murphy lab; my Ph.D. work was on a mouse model of mania. I sometimes miss the mice, but I have also come to love the worms (especially how quickly I can get stuff done). In the lab, I am almost always performing learning and memory assays, and I have also been working with the new tissue-specific RNA-seq protocols that we have developed. Outside of the lab, I am generally in search of good food, drink (craft beer!), and coffee. I also spend a lot of time doting on my adorable dog, and getting outside to run, walk, or hike whenever possible. I am also one of the fairly large number of soccer fans in the lab, so we may have games on in the background whenever the World Cup, Euro, or Olympics roll around.

Selected Publications

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Li, L., Lei, H., Arey, R.N., Li, P., Liu, J., Murphy, C.T., Xu, S.X.Z., and Shen, K. The neuronal kinesin UNC-104/KIF1A is a key regulator of synaptic aging and insulin signaling-related memory. Current Biology (2016) in press.  co‑corresponding authors.

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Kaletsky, R., Lakhina, V., Arey, R., Williams, A., Landis, J., Ashraf, J., and Murphy, C.T. The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators. Nature (2015) Dec 14; 529(7584):92-96. These authors contributed equally to this work.

Research Highlight
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Lakhina, V., Arey, R.N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C.T. Genome-wide Functional Analysis of CREB/Long-Term Memory-Dependent Transcription Reveals Distinct Basal and Memory Gene Expression Programs. Neuron (2015) Jan 21; 85(2): 330-345. These authors contributed equally to this work.

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Arey, R.N., Enwright, J.F. 3rd, Spencer, S.M., Falcon, E., Ozburn, A.R., Ghose, S., Tamminga, C., and McClung, C.A. An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors. Molecular Psychiatry (2014) Mar; 19(3): 342-350.

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Arey, R.N. and McClung, C.A. An inhibitor of casein kinase 1 ε/δ partially normalizes the manic-like behaviors of the ClockΔ19 mouse. Behavioral Pharmacology (2012) Aug; 23(4): 392-396.