What governs how fast we age? Why do some biological processes stop working earlier than others? And what is happening at the molecular and cellular level as some organisms age while others continue to thrive?
Although seemingly philosophical in nature, these questions address one of the major mysteries of biology, the process of aging. With recent developments in genetics, molecular biology, and genomics, we now have the possibility of addressing these questions at the molecular level. Because our ultimate goal is not simply to extend lifespan, but to improve overall health, we must identify the genes associated with biological functions that we typically associate with quality of life. The goal of our laboratory's work is to understand the molecular mechanisms governing longevity and maintenance of the biological processes that exhibit age-related decline.
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Shi, C., Runnels, A.M., and Murphy, C.T.
Mating and Male pheromone kill Caenorhabditis males through distinct mechanisms.
eLIFE (2017) Mar 14;6. pii: e23493.
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Son, H.G., Seo, M., Ham, S., Hwang, W., Lee, D., An, S.W., Artan, M., Seo, K., Kaletsky, R., Arey, R.N., Ryu, Y., Ha, C.M., Kim, Y.K., Murphy, C.T., Roh, T.Y., Nam, H.G., and Lee, S.V.
RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
Nature Communications (2017) Mar 9;8:14749
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Arey, R.N., and Murphy, C.T.
Conserved regulators of cognitive aging: From worms to humans.
Behavioural Brain Research (2017) Mar 30;322(Pt B):299-310.
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Shi, C., and Murphy, C.T. Feeding the germline.
Genes & Development (2016) Feb 1;30(3):249-50.
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Crocker, A., Guan, X.J., Murphy, C.T., and Murthy, M. Cell Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression. Cell Reports (2016) accepted.
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Li, L., Lei, H., Arey, R.N., Li, P., Liu, J., Murphy, C.T., Xu, S.X.Z., and Shen, K.
The neuronal kinesin UNC-104/KIF1A is a key regulator of synaptic aging and insulin signaling-related memory.
Current Biology (2016) in press.
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Shi, C., Runnels, A.M., and Murphy, C.T.
Mating-induced Male Death and Pheromone Toxin-related Androstasis.
bioRxiv (2016) preprint.
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DiLoreto, R., and Murphy, C.T.
The Cell Biology of Aging.
Molecular Biology of the Cell (2015) Dec 15; 26(25):4524-31.
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Kaletsky, R.†, Lakhina, V.†, Arey, R., Williams, A., Landis, J., Ashraf, J., and Murphy, C.T.
The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators.
Nature (2015) Dec 14; 529(7584):92-96. †These authors contributed equally to this work.
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Wang, J., Kaletsky, R., Silva, M., Williams, A., Haas, L.A., Androwski, R.J., Landis, J.N., Patrick, C., Rashid, A., Santiago-Martinez, D., Gravato-Nobre, M., Hodgkin, J., Hall, D.H., Murphy, C.T., and Barr, M.M.
Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis.
Current Biology (2015) Dec 21; 25(24):R1168-1170.
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Lakhina, V., and Murphy, C.T.
Genome Sequencing Fishes out Longevity Genes.
Cell (2015) Dec 3; 163(6):1312-1313.
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Hahm, J.H., Kim, S.†, DiLoreto, R.†, Shi, C.†, Murphy C.T.‡, and Nam, H.G.‡
C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation.
Nature Communications (2015) Nov 20; 6:8919. †These authors contributed equally to this work. ‡ co-corresponding authors.
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