Shi C, Murphy CT. (2014) Mating induces shrinking and death in Caenorhabditis mothers. Science. 2014 Jan 31; 343: (6170):536-40. doi: 10.1126 Science.1242958. Epub 2013 Dec 19.
Abstract | Reprint  [Pubmed]

Tepper RG, Murphy CT, Bussemaker HJ., (2014) DAF-16 and PQM-1: Partners in longevity. Aging (Albany NY) 6: 5-6 [Pubmed]

Murphy CT, Hu PJ. (2013) Insulin/insulin-like growth factor signaling in C. elegans. WormBook. Dec 26:1-43. doi: 10.1895 Wormbook.1.164.1. PMID: 24395814 Dec 26: 1-43. [Pubmed]

Tepper RG(1), Ashraf J (1), Kaletsky R, Kleemann G, Murphy CT(2), Bussemaker HJ.(2) (Aug 1, 2013) PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity. Cell. 154(3):676-90. doi: 10.1016 /J.Cell. 2013.07.006. [PubMed]
(1)Co-first author
(2)Co-corresponding author

Blackstone C and Murphy CT (March 15, 2012). "Cell biology of disease and aging: a two-way street." Molecular Biology of the Cell, v 23, no 975 10.1091/mbc.E11-12-0985 [Molecular Biology of the Cell]

Stein GM and Murphy CT (2012) . "The intersection of aging, longevity pathways, and learning and memory in C. elegans." Front. Gene. 3:259. doi: 10.3389/fgene.2012. 0259 [Frontiers in Genetics and Aging]

Liu G, Rogers J, Murphy C.T., Rongo C. (2011) "EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan." EMBO J. 2011 Jun 14. doi: 10.1038/emboj.2011.195. [Epub ahead of print]
PMID:  21673654  [PubMed - as supplied by publisher] [PubMed]

Rizki, G., Iwata, T.N., Li, J., Riedel, C.G., Picard, C.L., Jan, M., Murphy, C.T., and Lee, S.S. (2011) "The Evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO." PLoS Genetics, 2011 Sep;7(9):e1002235. Epub 2011 Sep 1. [PubMed]

Luo S., and Murphy C.T. (2011). "C. elegans Reproductive Aging: Regulation and Underlying Mechanisms."Genesis Feb;49(2):53-65.doi: 10.1002/dvg.20694. Epub 2011 Jan 2 [PubMed]

Kauffman A. L., Parsons L, Stein G.M., Wills A. A., Kaletsky R. L. and Murphy C. T. (2011). "C. elegans Positive Butanone Learning, Short-term, and Long-term Associative Memory Assays." J.Vis. Exp.49,doi: 10.3791/2490 [JoVE]

Luo S., Kleemann G.A., Ashraf J.M., Shaw W.M., and Murphy C.T. (2010). "TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance." Cell. 2010 Oct 15;143(2):299-312.
PMID: 20946987 [PubMed - indexed for MEDLINE] [PubMed]

Research Highlight: Cell Press, Nature News &Views, New York Times

Kauffman A.L., Ashraf J.M., Corces-Zimmerman M.R., Landis J.N. and Murphy C.T. (2010). "Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age." PLoS Biol 8(5): e1000372. doi:10.1371/journal.pbio.1000372 [PLOS] [PDF] [PubMed]

Research Highlight: Nature Reviews Neuroscience

Kaletsky, R. and Murphy, C.T. (2010). "The role of insulin/IGF-like signaling in C. elegans longevity and aging." Disease Models & Mechanisms (2010) [PubMed] [PDF]

Landis, J.N. and Murphy, C.T. (2010). "Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO." Dev Dyn. 2010 Feb 5. [Epub ahead of print] [PubMed] [PDF]

Luo, S., Shaw, W. M., Ashraf, J., Murphy, C. T. (2009).  "TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging." PLoS Genet. 2009 Dec. 5 (12):e1000789. Epub 2009 Dec 24. [PubMed] [PDF]

**Oliveira, R.P., **Abate. J.P., **Dilks, K., Landis J. and Ashraf, J. (**co-first authors), *Murphy, C.T., and *Blackwell K. T. (*co-corresponding authors) (2009) "Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf." Aging Cell. 2009 Jul 3. [Epub ahead of print] [PubMed] [PDF]

Chikina, M. D., Huttenhower, C., *Murphy, C. T., and *Troyanskaya, O. G. (*co-corresponding authors) (2009) "Global Prediction of Tissue-Specific Gene Expression and Context-Dependent Gene Networks in Caenorhabditis elegans" PLoS Comput Biol 5(6): e1000417. [PLOS] [PDF]

Kleeman, G. A. and Murphy, C. T. (2009) “The endocrine regulation of aging in Caenorhabditis elegans. Molecular and Cellular Endocrinology 299: 51-57. [PubMed] [PDF]

Shaw, W.M., Luo, S., Landis, J., Ashraf, J., and Murphy, C. T. (2007) “The C. elegans TGF-ß Dauer Pathway Regulates Longevity via Insulin Signaling.” Current Biology, Oct 9;17(19):1634-45. [PubMed]   [PDF]

Murphy, C. T. (2006).  "The Search for DAF-16/FOXO Transcriptional Targets: Approaches and Discoveries."  Experimental Gerontology 2006 Oct;41(10):910-21. Epub 2006 Aug 24.   [PubMed]   [PDF]

Murphy, C. T. (2006).  "Using Whole-Genome Transcriptional Analyses to Discover Molecular Mechanisms of Aging."  Drug Discovery Today: Disease Mechanisms  3(1): 41-46.   [PDF]

Kenyon, C. and Murphy, C. T. (2006).  "Enrichment of regulatory motifs upstream of predicted DAF-16 targets."  Nature Genetics  38(4): 397-8.   [PubMed]   [PDF]

Murphy, C. T. (2005).  "A Review of Genes that Act Downstream of the DAF-16 FOXO transcription factor to influence the lifespan of C. elegans."   Research and Perspectives in Longevity,  Longevity and Frailty, Springer.   [PDF]

Post-doctoral work with Cynthia Kenyon, UCSF

Lee, S. J., Murphy, C. T., Kenyon, C. (2009).  "Glucose shortens the lifespan of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression." Cell Metabolism 2009 Nov;10(5):379-91. [PubMed]   

Murphy, C. T., Lee, S.J., and Kenyon, C. (2007) “Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans." PNAS. 104(48): 19046-50. [PDF]

McCarroll, S. A., Murphy, C. T., et al. (2004).  "Comparing genomic expression patterns across species identifies shared transcriptional profile in aging."   Nature Genetics  36(2): 197-204.   [PubMed]   [PDF]

Murphy, C. T., McCarroll, S., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., Kenyon, C. (2003).  "Genes that Act Downstream of DAF-16 to Influence the Lifespan of C. elegans."   Nature 424: 277-83.   [PubMed]   [PDF]

Hsu, A. L., Murphy, C. T., and Kenyon, C. (2003).  "Regulation of aging and age-related disease by DAF-16 and heat-shock factor."   Science 300: 1142-5.   [PubMed]   [PDF]

Graduate work with James A. Spudich, Stanford

Murphy, C. T., Rock, R. S., and Spudich, J. A. (2001).  "A Myosin II Mutation Uncouples ATPase activity from Motility and Shortens Step Size."   Nature Cell Biology 3: 311-315.   [PubMed]   [PDF]

Murphy, C. T. and Spudich, J. A. (2000).  "Variable Surface Loops and Myosin Activity: Accessories to a Motor."   J. Mus. Res. Cell Mot. 21: 139-151.   [PubMed]   [PDF]

Murphy, C. T. and Spudich, J. A. (1999).  "The Sequence of the Myosin 50-20K Loop Affects Myosin’s Affinity for Actin throughout the Actin-Myosin ATPase Cycle and Its Maximum ATPase Activity."   Biochemistry 38(12): 3785-3792.   [PubMed]   [PDF]

Murphy, C. T. and Spudich, J. A. (1998).  "Dictyostelium Myosin 25-50K Loop Substitutions Specifically Affect ADP Release Rates."   Biochemistry 37(19): 6738-6744.   [PubMed]   [PDF]