Biker worm Boarder worm Striker worm Swimmer worm

the murphy lab
@ Princteon University

The Murphy Lab gathered together outside the Carl Icahn Laboratory

What governs how fast we age? Why do some biological processes stop working earlier than others? And what is happening at the molecular and cellular level as some organisms age while others continue to thrive?

Although seemingly philosophical in nature, these questions address one of the major mysteries of biology, the process of aging. With recent developments in genetics, molecular biology, and genomics, we now have the possibility of addressing these questions at the molecular level. Because our ultimate goal is not simply to extend lifespan, but to improve overall health, we must identify the genes associated with biological functions that we typically associate with quality of life. The goal of our laboratory's work is to understand the molecular mechanisms governing longevity and maintenance of the biological processes that exhibit age-related decline.

Part of the:

Department of Molecular Biology

Department of Molecular Biology

at Princeton University
Lewis-Sigler Institute for Integrative Genomics

Lewis-Sigler Institute

for Integrative Genomics
Paul F. Glenn Foundation Laboratories for Aging Research at Princeton University

Paul F. Glenn Foundation

Laboratories for Aging Research
at Princeton University

Recent publications

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Li, L., Lei, H., Arey, R.N., Li, P., Liu, J., Murphy, C.T., Xu, S.X.Z., and Shen, K. The neuronal kinesin UNC-104/KIF1A is a key regulator of synaptic aging and insulin signaling-related memory. Current Biology (2016) in press.

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Shi, C., Runnels, A.M., and Murphy, C.T. Mating-induced Male Death and Pheromone Toxin-related Androstasis. bioRxiv (2016) preprint.

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DiLoreto, R., and Murphy, C.T. The Cell Biology of Aging. Molecular Biology of the Cell (2015) Dec 15; 26(25):4524-31.

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Kaletsky, R., Lakhina, V., Arey, R., Williams, A., Landis, J., Ashraf, J., and Murphy, C.T. The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators. Nature (2015) Dec 14; 529(7584):92-96. These authors contributed equally to this work.

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Wang, J., Kaletsky, R., Silva, M., Williams, A., Haas, L.A., Androwski, R.J., Landis, J.N., Patrick, C., Rashid, A., Santiago-Martinez, D., Gravato-Nobre, M., Hodgkin, J., Hall, D.H., Murphy, C.T., and Barr, M.M. Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis. Current Biology (2015) Dec 21; 25(24):R1168-1170.

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Lakhina, V., and Murphy, C.T. Genome Sequencing Fishes out Longevity Genes. Cell (2015) Dec 3; 163(6):1312-1313.

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Hahm, J.H., Kim, S., DiLoreto, R., Shi, C., Murphy C.T., and Nam, H.G. C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation. Nature Communications (2015) Nov 20; 6:8919. These authors contributed equally to this work. co-corresponding authors.