ResearchProbing the host response to herpesviruses using microarraysThe Enquist lab is investigating the host response to alphaherpesviruses such as PRV and HSV-1 using microarray technology. Here are links and abstracts of our recent work. Check back for more as our research progresses. 2004. Transcriptional response of a common permissive cell type to infection by two diverse alphaherpesviruses. J. Virol., 78(7):3489-3501. A study of how gene expression in rat embryonic fibroblasts changes during infection by either PRV or HSV-1. This study used Affymetrix rat RGU34A arrays. Click the PubMed ID above for the abstract and link to the paper. Click the PUMAdb link above for access to all the data from these experiments. 2004. Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus. J. Virol., 78(23):12964-12974. This study followed up one of the largest increases in gene expression observed during PRV infection in the study above, that of cyclooxygenase-2 (COX-2), and investigated how inhibiting COX-2 in turn affects PRV. Click the PubMed ID above for the abstract and link to the paper. 2006. The Transcriptome Signature of Virulent and Attenuated Pseudorabies Virus- Infected Rodent Brain. J. Virol., accepted, in press
A study of the host response to infection by one of three PRV strains (Becker, Bartha, and PRV99 – a gE/gI deleted strain), using an in vivo rat eye model of infection. Gene expression responses of whole tissue from hypothalamus and cerebellum were examined using Affymetrix rat RG-U34A arrays. Click the PUMAdb link above to view the abstract for this paper and for access to all the data from these experiments. Once the paper is published, the link to its PubMed ID and online citation will be activated.. |
